Focus of the Report: This report focuses on the efficacy and safety of the 5-hydroxytryptamine 1F (5-HT1F) receptor agonist lasmiditan (Reyvow) for acute treatment of migraines.
Technology Description: The 5-HT1F receptors are…
Health Technology Assessments
Health Technology Assessments (HTAs) are a comprehensive systematic review and critical analysis of available evidence for A SINGLE medical technology for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more indications or patient populations in use.
Our analysts evaluate clinical trial data, along with information regarding safety issues, coverage policies from the private and public sectors, regulatory approvals, consensus statements, and an overall projection of the potential clinical efficacy and economic impact of the technology. Reports are reviewed annually up to 5 years post publication to determine if there is new literature or evidence that would impact a change in rating and warrant an updated report.
Ubrogepant (Ubrelvy) for Acute Migraine Treatment
Focus of the Report: This report focuses on the efficacy and safety of the calcitonin gene-related peptide (CGRP) receptor antagonist ubrogepant (Ubrelvy) for acute treatment of migraines.
Technology Description: Ubrogepant is approved for the acute treatment of migraine. Ubrogepant is a C…
Axicabtagene Ciloleucel (Yescarta) for Treatment of Relapsed or Refractory B-Cell Malignancies
Focus of the Report: This report evaluates the use of axicabtagene ciloleucel (Yescarta) for the treatment of relapsed or refractory (r/r) large B-cell lymphoma (LBCL).
Technology Description: Axicabtagene ciloleucel therapy is a form of chimeric antigen receptor (CAR) T-lymphocyte (T-…
Noninvasive Computed Fractional Flow Reserve from Computed Tomography (FFRCT) for Diagnosis of Coronary Artery Disease
Focus of the Report: This report focuses on fractional flow reserve (FFR), determined noninvasively via computed tomography (FFRCT), to detect coronary artery blockages, identified by coronary computed tomography angiography (CCTA), that may be responsible for myocardial ischemia in patients with known or suspected coronary artery disease (CA…
Percutaneous Mitral Valve Repair for Secondary (Functional) Mitral Valve Regurgitation in High-Risk Adults
Focus of the Report: This report focuses on the use of the MitraClip Mitral Valve Repair System (Abbott Vascular Inc.) for treatment of secondary (or functional) mitral valve regurgitation (MR).
Technology Description: The MitraClip Mitral Valve Repair System is a minimally invasive d…
Transperineal Template Prostate Biopsy Following Negative Transrectal Biopsy
Focus of the Report: Transperineal template prostate (TTP) biopsy is an alternative to standard transrectal ultrasound (TRUS) biopsy for repeat biopsies. TTP biopsy is a form of saturation biopsy (at least 20 cores) that uses a brachytherapy grid to assure even distribution of the cores.
Tec…
Artificial Pancreas with the t:slim X2 for the Management of Diabetes Mellitus
Focus of the Report: This health technology assessment focuses on the use of t:slim X2 Insulin Pump and Dexcom 6 continuous glucose monitoring (CGM) with Control-IQ closed-loop control (CLC) or Basal-IQ predictive low-glucose suspend (PLGS) technology for the management of diabetes mellitus (DM).
Focus of the Report: This report focuses on Lee Silverman Voice Treatment (LSVT) LOUD for the treatment of patients with speech and voice problems resulting from Parkinson disease (PD). Technology Description: LSVT LOUD is an intensive voice therapy regimen that requires high patient e… Focus of the Report: The use of the MiniMed 670G Insulin Pump System for the management of diabetes mellitus (DM). Technology Description: An artificial pancreas (AP) or closed-loop system includes a continuous subcutaneous insulin infusion (CSII) pump, a continuous glucose monitor (CGM), … Focus of the Report: This report focuses on the use of liposuction (also called suction-assisted lipectomy) for the surgical treatment of patients with lymphedema. Technology Description: Liposuction is a reductive, minimally invasive, surgical procedure used to remove hypertrophied ad…Lee Silverman Voice Treatment (LSVT) LOUD for Speech and Voice Problems in Parkinson Disease
Artificial Pancreas with the MiniMed 670G for the Management of Diabetes Mellitus
Liposuction for the Reductive Surgical Treatment of Lymphedema