Our analysts evaluate clinical trial data, along with information regarding safety issues, coverage policies from the private and public sectors, regulatory approvals, consensus statements, and an overall projection of the potential clinical efficacy and economic impact of the technology. Reports are reviewed annually up to 5 years post publication to determine if there is new literature or evidence that would impact a change in rating and warrant an updated report.
Focus of the Report: This report focuses on bioimpedance analysis (BIA) for diagnosis, predicting development, selection of treatment, and monitoring of lymphedema (LE).
Technology Description: BIA measures the differential impedance (resistance) to low level electrical current to eval…
Focus of the Report: This Health Technology Assessment focuses on the efficacy and safety of a monoclonal antibody, erenumab (Aimovig), for prevention of episodic or chronic migraine.
Technology Description: Erenumab is a human calcitonin gene–related peptide (CGRP) receptor monoclonal antibody that is produced using recombinant DNA technology in cell …
Focus of the Report: This report evaluates the efficacy and safety of the gene replacement therapy onasemnogene abeparvovec-xioi (Zolgensma or AVXS-101) for treatment of patients with spinal muscular atrophy (SMA) type 1.
Technology Description: Onasemnogene abeparvovec is a single-dos…
Focus of the Report: This report compares the effectiveness and safety of skin substitutes (cellular and acellular) as an addition to standard wound care (SWC) with SWC alone and compared with the adjunct use of alternative skin substitute products to treat chronic or nonhealing venous leg ulcers in adults.
Focus of the Report: This report evaluates the use of tisagenlecleucel (Kymriah) for the treatment of relapsed or refractory (r/r) B-cell acute lymphoblastic leukemia (ALL) or r/r diffuse large B-cell lymphoma (DLBCL).
Technology Description: Tisagenlecleucel therapy is a form of chime…
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Focus of the Report: This health technology assessment focuses on the use of genicular nerve blocks (GNB) for the management of knee pain associated with osteoarthritis of the knee (KOA) or persistent pain following total knee arthroplasty (TKA).
Technology Description: In a GNB proced…
Focus of the Report: This report focuses on electronic monitoring (EM) of hand hygiene (HH) in a hospital setting.
Technology Description: Electronic HH monitoring systems vary in their degree of sophistication. The simplest are straightforward counters that record the number of times …
Focus of the Report: This report focuses on magnetic resonance elastography (MRE) for diagnosis and staging of liver fibrosis.
Technology Description: MRE relies on visualization of the passage of sound waves through liver tissue while the patient is in a magnetic resonance imaging (MR…
Focus of the Report: This report focuses on the use of lymphovenous anastomosis (LVA) for the surgical treatment of patients with lymphedema.
Technology Description: LVA is a microsurgical procedure used to restore adequate lymphatic drainage from tissues of the upper or lower extremit…