Health Problem: Diabetes mellitus (DM) can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of even minor wounds to heal. Chronic foot ulcers in people with DM (DFU) may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Reasons …
Health Technology Assessments
Health Technology Assessments (HTAs) are a comprehensive systematic review and critical analysis of available evidence for A SINGLE medical technology for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more indications or patient populations in use.
Our analysts evaluate clinical trial data, along with information regarding safety issues, coverage policies from the private and public sectors, regulatory approvals, consensus statements, and an overall projection of the potential clinical efficacy and economic impact of the technology. Reports are reviewed annually up to 5 years post publication to determine if there is new literature or evidence that would impact a change in rating and warrant an updated report.
Cellular Skin Substitutes for Chronic Foot Ulcers in Adults with Diabetes Mellitus
Health Problem: Diabetes mellitus (DM) can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of even minor wounds to heal. Chronic foot ulcers in people with DM (DFU) may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Reasons …
Precision Pulse Capsulotomy (Zepto Capsulotomy System) for Anterior Capsulotomy During Cataract Surgery
Focus of the Report: The use of precision pulse capsulotomy (PPC) with the Zepto Capsulotomy System (Mynosys Cellular Devices Inc.) for anterior capsulotomy during cataract surgery in adults.
Technology Description: The Zepto Capsulotomy System is a nonlaser, low-energy discharge syste…
AposTherapy System (APOS Medical Assets Ltd.) for Treatment of Osteoarthritis of the Knee
Focus of the Report: The use of the AposTherapy System for the treatment of osteoarthritis of the knee (KOA).
Technology Description: The AposTherapy device is a foot-worn biomechanical device designed to redistribute the load away from painful areas in the knees, purportedly decreasin…
Subtalar Arthroereisis for the Treatment of Adult-Acquired Flatfoot Deformity
Focus of the Report: This report assesses subtalar arthroereisis (SA) for treating adults with symptomatic flatfoot (FF) deformity that does not respond to conservative measures and negatively impacts the patient’s ability to function in activities of daily living.
Technology Description:
Prokera (Bio-Tissue Inc.) for Treatment of Ocular Indications
Focus of the Report: This report evaluates the use of the ProKera device (Bio-Tissue Inc.) for the treatment of ocular indications.
Technology Description: ProKera is comprised of a cryopreserved human amniotic membrane graft that is fastened to an ophthalmic conformer without the use …
Autologous Microfragmented Adipose Tissue Injection for Treatment of Osteoarthritis
Focus of the Report: This report addressed the use of microfragmented adipose tissue (MFAT) as a stand-alone treatment via intra-articular injection for the treatment of osteoarthritis (OA).
Technology Description: To prepare MFAT for use in the joint, fat is extracted from another lo…
Proton Beam Therapy for Prostate Cancer
Focus of the Report: This report focuses on the use of proton beam therapy (PBT) to treat prostate cancer.
Technology Description: PBT is a type of external radiation treatment in which positively charged subatomic particles (protons) are precisely targeted to a specific tissue mass us…
Processed Nerve Allografts with the Avance Nerve Graft (Axogen Corporation) for Peripheral Nerve Discontinuities
Focus of the Report: This report addresses the use of processed nerve allografts (Avance Nerve Graft) for repair of peripheral nerve discontinuities.
Technology Description: The Avance Nerve Graft is a processed nerve allograft intended for bridging nerve discontinuities to support reg…
Negative Pressure Wound Therapy After Surgery for Pilonidal Disease
Focus of the Report: This report addresses the use of negative pressure wound therapy (NPWT) used in addition to standard wound care following surgery to treat pilonidal disease.
Technology Description: NPWT uses a device to apply subatmospheric pressure in a closed environment to cont…