Health Technology Assessments

Health Technology Assessments (HTAs) are a comprehensive systematic review and critical analysis of available evidence for A SINGLE medical technology for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more indications or patient populations in use.

Our analysts evaluate clinical trial data, along with information regarding safety issues, coverage policies from the private and public sectors, regulatory approvals, consensus statements, and an overall projection of the potential clinical efficacy and economic impact of the technology. Reports are reviewed annually up to 5 years post publication to determine if there is new literature or evidence that would impact a change in rating and warrant an updated report.

Measurement of Corneal Hysteresis for the Diagnosis and Management of Glaucoma

Health Problem: Glaucoma is a group of ocular disorders that causes progressive damage to the optic nerve, which results in loss of vision. Glaucoma is the second leading cause of blindness worldwide, with as many as 6 million people blind in both eyes due to this condition. In the United States, more than 3 million people have glaucoma, among whom up to half are unaware that …

Magnetically Controlled Growing Rods for Treatment of Early-Onset Scoliosis

Health Problem: Early-onset scoliosis (EOS) affects skeletally immature patients younger than 10 years of age. Patients with EOS are still undergoing development, which can place them at risk for progression of the deformity. If EOS progresses to a severe state, the spine can crowd the space within the chest cavity, and can cause thoracic insufficiency syndrome (TIS), where th…

Pneumatic Compression for Prevention of Deep Vein Thrombosis Following Knee Arthroplasty

Health Problem: A venous thromboembolism (VTE) is a blood clot resulting from slowed circulation, which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). A DVT forms in a deep vein, usually the leg or pelvis, increasing the risk of morbidity and mortality after orthopedic surgery. Following total knee arthroplasty (TKA), 40% to 84% of patients develop a DVT…

Percutaneous Sacroplasty for Treatment of Sacral Insufficiency Fractures

Health Problem: Sacral insufficiency fractures (SIFs) are fragility fractures of the sacrum that destabilize the pelvis and cause debilitating low back pain. The overall incidence of SIF is difficult to determine; however, one estimate suggests that 19% of patients aged > 70 years who underwent bone scan had an SIF.

Technology Description:

Inhaled Nitric Oxide for the Treatment of Respiratory Failure in Preterm Newborns

Health Problem: Respiratory distress syndrome (RDS) is one of the most common causes of preterm infant respiratory failure and mortality, with RDS occurring in 20,000 to 30,000 newborn infants annually in the United States. RDS results from developmental immaturity of the lungs, which leads to insufficient surfactant production and function. …