Focus of the Report: The use of minimally invasive sacroiliac joint (SIJ) fusion with cylindrical threaded implants (CTIs) for the treatment of adults with SIJ dysfunction who have not experienced adequate relief from nonsurgical management (NSM). Evaluation of minimally invasive SIJ fusion using triangular titanium implants (i.e., iFuse Impl…
Evidence Analysis
It is a challenge for health plans and clinicians to distill and analyze volumes of clinical evidence to determine likely clinical, financial, and risk impacts. This is what we do.Accessed through the Hayes Knowledge Center, the Evidence Analysis Solution addresses the following fundamental questions to help our clients determine coverage positions:
- Does the technology improve health outcomes?
- Are there other benefits associated with the technology?
- What harms might be associated with the technology?
- Have patient selection criteria been established for the technology?
- For which patients might the technology provide a benefit?
- Health Technology Assessments
- Evidence Analysis Research Briefs
- Evolving Evidence Review
- Clinical Research Responses
Voretigene Neparvovec-rzyl (Luxturna) for Inherited Retinal Dystrophies
Focus of the Report: This report evaluates the use of voretigene neparvovec-rzyl (Luxturna) for the treatment of vision loss due to inherited retinal dystrophies (IRDs) from confirmed biallelic RPE65 mutations.
Technology Description: Voretigene neparvove…
Amniotic Allografts for Tendon and Ligament Injuries
Focus of the Report: This report focuses on amniotic allograft (AA) for treatment or prevention of tendon and ligament injuries.
Technology Description: AA is prepared from sheets of amniotic membrane obtained shortly after caesarean delivery. For some products, amniotic membrane is de…
Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants (iFuse Implant System, SI-Bone Inc.)
Focus of the Report: The use of minimally invasive sacroiliac joint (SIJ) fusion with the iFuse Implant System (SI-Bone Inc.) for the treatment of adults with SIJ dysfunction who have not experienced adequate relief from nonsurgical management (NSM).
Technology Description: The iFuse i…
Matrix-Induced Autologous Chondrocyte Implantation (MACI) Procedure for Repair of Articular Cartilage of the Knee
Focus of the Report: This report focuses on matrix-induced autologous chondrocyte implantation (MACI) for the treatment of patients with chondral defects of the knee.
Technology Description: MACI is a multi-stage procedure that involves 2 surgeries. During an initial arthroscopic surge…
Deep Brain Stimulation for the Treatment of Refractory Obsessive-Compulsive Disorder
Focus of the Report: The use of deep brain stimulation (DBS) for treatment of refractory obsessive-compulsive disorder (OCD).
Technology Description: DBS therapy uses mild electrical impulses to regulate electrical activity of neural circuits. Patients undergo surgery to implant a med…
Bioelectrical Impedance (Bioimpedance) Analysis for Assessment of Lymphedema
Focus of the Report: This report focuses on bioimpedance analysis (BIA) for diagnosis, predicting development, selection of treatment, and monitoring of lymphedema (LE).
Technology Description: BIA measures the differential impedance (resistance) to low level electrical current to eval…
Erenumab (Aimovig) for Prevention of Episodic or Chronic Migraine
Focus of the Report: This Health Technology Assessment focuses on the efficacy and safety of a monoclonal antibody, erenumab (Aimovig), for prevention of episodic or chronic migraine.
Technology Description: Erenumab is a human calcitonin gene–related peptide (CGRP) receptor monoclonal antibody that is produced using recombinant DNA technology in cell …
Onasemnogene Abeparvovec-xioi (Zolgensma) for Spinal Muscular Atrophy
Focus of the Report: This report evaluates the efficacy and safety of the gene replacement therapy onasemnogene abeparvovec-xioi (Zolgensma or AVXS-101) for treatment of patients with spinal muscular atrophy (SMA) type 1.
Technology Description: Onasemnogene abeparvovec is a single-dos…
Skin Substitutes for Venous Leg Ulcers in Adults
Focus of the Report: This report compares the effectiveness and safety of skin substitutes (cellular and acellular) as an addition to standard wound care (SWC) with SWC alone and compared with the adjunct use of alternative skin substitute products to treat chronic or nonhealing venous leg ulcers in adults.