Evidence Analysis

It is a challenge for health plans and clinicians to distill and analyze volumes of clinical evidence to determine likely clinical, financial, and risk impacts. This is what we do.

Accessed through the Hayes Knowledge Center, the Evidence Analysis Solution addresses the following fundamental questions to help our clients determine coverage positions:

  • Does the technology improve health outcomes?
  • Are there other benefits associated with the technology?
  • What harms might be associated with the technology?
  • Have patient selection criteria been established for the technology?
  • For which patients might the technology provide a benefit?

Fractional Laser Treatment of Burn and Traumatic Scars for Functional Improvement

Health Problem: The 2 most problematic abnormal scars include keloids and hypertrophic scars, which may cause contracture leading to dysfunction and disfigurement. The incidence of hypertrophic scarring is estimated to occur in 91% of burn injuries.

Technology Description: Fractional carbon dioxide and erbium-doped yttrium aluminum garnet lasers are com…

Comparative Effectiveness Review of Bronchoscopically Placed Coils or Valves for Lung Emphysema: A Review of Reviews

Health Problem: Chronic obstructive pulmonary disease (COPD) is a progressive, obstructive respiratory disorder in which airways are clogged with mucus; airways and alveoli lose elasticity; or alveoli are thickened, inflamed, or destroyed. Signs and symptoms include ongoing cough, often producing mucus; shortness of breath; audible breathing such as wheezing, whistling, or squ…

Vagus Nerve Stimulation for Treatment-Resistant Depression

Vagus nerve stimulation (VNS) is a therapy for treatment-resistant major depression and bipolar disorder in which an implanted generator, the neurocybernetic prosthesis, delivers electrical pulses to the cervical portion of the vagus nerve. The goal of VNS is to reduce the severity and/or duration of a depressive period.

Comparative Effectiveness Review of Prostatic Artery Embolization (PAE) for Treatment of Benign Prostatic Hypertrophy (BPH)

Health Problem: Benign prostatic hyperplasia (BPH) is an enlargement or growth of the prostate gland. An enlarged prostate restricts the urethra and applies pressure on the base of the bladder. This restriction of the urethra can interfere with urination and eventually cause more serious problems.

Zio Patch (iRhythm Technologies Inc.) Long-Term Ambulatory Cardiac Rhythm Monitoring

Health Problem: Cardiac arrhythmias occur when there is abnormal formation or conduction of electrical impulses in the myocardium. General types of arrhythmias include bradycardia, tachycardia, and heart block. Atrial fibrillation (AF) is 1 of the most common arrhythmias, with an estimated prevalence of 2.7 to 6.1 million pe…

Proton Beam Therapy for Treatment of Pituitary Adenomas

Health Problem: Tumors originating in the pituitary are the fourth most common type of intracranial tumor. The majority are slow-growing benign adenomas that do not metastasize. Symptoms from pituitary adenomas (PAs) result from endocrine dysfunction or compression of brain structures as the tumor enlarges, which may result in significant morbidity.

Technology D…

Transcutaneous Electrical Nerve Stimulation for Knee Osteoarthritis

Health Problem: Knee osteoarthritis (KOA) develops via progressive destruction of the cartilage lining the knee joints, subchondral bone surfaces, and synovium. KOA causes pain, immobility, muscle weakness, decreased function, and impaired ability to complete activities of daily living. Symptomatic KOA has a prevalence rate of 12% in adults aged 60 years or greater. KOA negati…

Comparative Effectiveness Review of Bariatric Surgeries for Treatment of Obesity in Adolescents

Health Problem: Child and adolescent obesity is a body mass index (BMI) at or above the sex-specific 95th percentile on BMI-for-age growth charts. Consequences of obesity in children and adolescents include type 2 diabetes mellitus, obstructive sleep apnea, hypertension, nonalcoholic fatty liver disease, hyperlipidemia, musculoskeletal disorders, endocrine conditions, psycholo…

Ultrasound-Guided Percutaneous Carpal Tunnel Release for Treatment of Carpal Tunnel Syndrome

Health Problem: Carpal tunnel syndrome (CTS) is a compression neuropathy of the median nerve at the wrist. It is characterized by increased pressure within the carpal tunnel and decreased function of the nerve. The estimated prevalence of CTS is 3.1% to 7.8% among adult workers, with higher prevalence among female and older-age workers.

Technology Description: <...