Evidence Analysis

It is a challenge for health plans and clinicians to distill and analyze volumes of clinical evidence to determine likely clinical, financial, and risk impacts. This is what we do.

Accessed through the Hayes Knowledge Center, the Evidence Analysis Solution addresses the following fundamental questions to help our clients determine coverage positions:

  • Does the technology improve health outcomes?
  • Are there other benefits associated with the technology?
  • What harms might be associated with the technology?
  • Have patient selection criteria been established for the technology?
  • For which patients might the technology provide a benefit?

Comparative Effectiveness Review of Bupivacaine Liposome Injectable Suspension for Relief of Postoperative Pain Following Total Knee Arthroplasty: A Review of Reviews

Health Problem: More than 70 million surgical procedures are performed annually in the United States. Fewer than half of patients who undergo surgery report adequate postoperative pain relief. Controlling postoperative pain increases patient mobility, permits earlier return to activities of daily living, and reduces the risk for postoperative complications. According to 2010 s…

Sex Reassignment Surgery for the Treatment of Gender Dysphoria

Health Problem: In people with gender identity disorder (GID), formerly called transsexualism, there is severe incongruity between anatomical sex and gender identity. Individuals with GID have persistent discomfort with his or her anatomical sex, usually beginning in childhood. The discomfort or stress caused by this incongruity is gender dysphoria (GD).

Technol…

Fetal Surgery for Myelomeningocele

Health Problem: Myelomeningocele (MMC) is the most severe form of spina bifida, in which the neural tube does not completely close and a sac of fluid, including cerebrospinal fluid, meninges, and possibly damaged parts of the spinal cord and nerves, protrudes through an opening in the baby’s back. Moderate-to-severe disabilities accompany MMC, including impaired cognition, uri…

Fetal Surgery for Congenital Diaphragmatic Hernia

Health Problem: Congenital diaphragmatic hernia (CDH) is an abnormal development of the diaphragm that allows for organs such as the stomach, liver, and bowel to protrude into the chest cavity. Pulmonary hypoplasia (lung underdevelopment) and impaired function result, leading to respiratory insufficiency and possibly causing potentially fatal persistent pulmonary hypertension….

Comparative Effectiveness Review of Stem Cell Therapy for Joint Pain

Health Problem: Spinal discs and the cartilage that covers mobile joints can become damaged by chronic strain, overuse, trauma, and diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA) causing pain and disability.

Technology Description: Stem cells used for treatment of joint pain can be harvested from iliac crest bone marrow, adipose tiss…

Comparative Effectiveness Review of Bupivacaine Liposome Injectable Suspension for Relief of Postoperative Pain Following Total Hip or Shoulder Arthroplasty

Health Problem: Fewer than half of the 70 million patients who undergo surgery in the United States every year report adequate postoperative pain relief. Controlling postoperative pain increases patient mobility, permits earlier return to activities of daily living, and reduces the risk for postoperative complications. Increasing awareness of issues on the safety of opioids ha…