Vowst (fecal microbiota spores, live-brpk; Seres Therapeutics Inc.) is an oral capsule containing fecal microbiota spores indicated to prevent the recurrence of Clostridioides difficile infection (CDI) in individuals 18 years of age and older following antibacterial treatment for recurrent CDI (rCDI).
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Pentosan Polysulfate Sodium (Paradigm Biopharmaceuticals Ltd.) for Knee Osteoarthritis
Pentosan polysulfate sodium (proposed name, Zilosul) is a subcutaneously injected semisynthetic glucosaminoglycan under investigation for treatment of knee osteoarthritis.
ExoDx Prostate Test (Exosome Diagnostics Inc.)
This report evaluates the clinical validity and clinical utility of the ExoDx Prostate test (Exosome Diagnostics Inc.).
Tofersen (Qalsody; Biogen) for Amyotrophic Lateral Sclerosis
Tofersen (Qalsody; Biogen) is an intrathecally administered antisense oligonucleotide indicated for the treatment of amyotrophic lateral sclerosis (ALS) in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene (SOD1-ALS).
Prostatic Artery Embolization for Treatment of Benign Prostatic Hyperplasia
Focus of the Report: The focus of this Health Technology Assessment is evaluation of the effectiveness and safety of prostatic artery embolization (PAE) compared with open prostatectomy and minimally invasive approaches to treat moderate-to-severe benign prostatic hyperplasia (BPH).
Technolog…
GeneStrat (Biodesix Inc.)
This report evaluates the clinical validity and clinical utility of the GeneStrat targeted genomic test (Biodesix Inc.).
Luminopia One (Luminopia Inc.) for Treatment of Amblyopia in Children
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of Luminopia One (Luminopia Inc.) for the treatment of amblyopia in children aged 4 to 7 years to improve visual acuity.
Blarcamesine for Rett Syndrome
Blarcamesine (ANAVEX 2-73) is an investigational oral drug that targets sigma-1 and muscarinic receptors. It is in development for the treatment of Rett syndrome as well as for a number of other central nervous system disorders.
Maintenance Repetitive Transcranial Magnetic Stimulation for Prevention of Recurrent Depression in Adults
Focus of the Report: The focus of this Health Technology Assessment is to evaluate the effectiveness and safety of maintenance repetitive transcranial magnetic stimulation (rTMS) compared with sham rTMS, pharmacotherapy, or combination therapy to prevent the recurrence of major depressive disorder (MDD) in adults.
Lenire Device (Neuromod Devices Ltd.) for Tinnitus
Lenire is a bimodal neuromodulation device combining sound and transmucosal electrical tongue stimulation to temporarily relieve the symptoms of tinnitus in patients ≥ 18 years of age with at least moderate tinnitus. Lenire therapy is intended to be self-administered by the patient following prescription by a healthcare professional who is experienced in the evaluation and ma…