Botaretigene sparoparvovec is an investigational gene replacement therapy for the treatment of X-linked retinitis pigmentosa due to mutations in the RPGR gene. It is administered by subretinal injection.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Signatera (Natera Inc.)
This report evaluates the clinical validity and clinical utility of the Signatera test.
Laser Interstitial Thermal Therapy for Treatment of Brain Radiation Necrosis
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of laser interstitial thermal therapy (LITT), also known as stereotactic laser ablation (SLA), for the treatment of brain radiation necrosis (RN).
EndeavorRx (Akili Interactive Labs Inc.) for Treatment of Attention-Deficit/Hyperactivity Disorder in Children
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of EndeavorRx (Akili Interactive Labs Inc.) to improve attention function in children with attention-deficit/hyperactivity disorder (ADHD).
Amvuttra (Vutrisiran) for Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis
Amvuttra (vutrisiran) is an injectable RNA interference (RNAi) therapeutic agent indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.
leva Pelvic Health System (Renovia Inc.) for Treatment of Urinary Incontinence
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of the leva Pelvic Health System (Renovia Inc.) for the treatment of urinary incontinence (UI) in female patients.
VivAer (Aerin Medical Inc.) for Nasal Airway Remodeling to Treat Nasal Obstruction
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of VivAer (Aerin Medical Inc.) for the treatment of nasal airway obstruction (NAO).
Theta Burst Stimulation for Treatment-Resistant Unipolar Depression in Adults
Focus of the Report: The focus of this Health Technology Assessment (HTA) is to evaluate the effectiveness and safety of theta burst stimulation (TBS), alone and compared with repetitive transcranial magnetic stimulation (rTMS) and/or with sham TBS, for the management of treatment-resistant major depressive disorder (MDD) (unipolar treatment-…
Laser Interstitial Thermal Therapy for Treatment of Recurrent Metastatic Brain Neoplasms
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of laser interstitial thermal therapy (LITT), also known as stereotactic laser ablation (SLA), for the treatment of recurrent metastatic brain neoplasms.
Trabecular Bone Score to Predict Fracture Risk in Postmenopausal Patients
Focus of the Report: The focus of this Health Technology Assessment is evaluation of the effectiveness and safety of the trabecular bone score (TBS) as an adjunct to bone mineral density (BMD) measurement and/or other validated tools incorporating patient information for prediction of fracture risk and guidance of preventive treatment in post…