Publications

Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.

Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.

See below for some of our recent publications.

Aduhelm (Aducanumab) for Early-Stage/Mild Alzheimer Disease

This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of aducanumab (Aduhelm; Biogen Inc.) for the treatment of patients with early-stage Alzheimer disease and mild cognitive symptoms.

Pegzilarginase for Arginase 1 Deficiency

Pegzilarginase is an investigational recombinant form of the human enzyme arginase 1 (ARG1) proposed for the treatment of pediatric and adult patients with ARG1 deficiency. It is administered by intravenous infusion or subcutaneous injection.

Percutaneous Pulmonary Valve Implantation with the Edwards Sapien 3 and Sapien XT Valves (Edwards Lifesciences Corp.) for Right Ventricular Outflow Tract Defects

Focus of the Report: This Health Technology Assessment focuses on percutaneous pulmonary valve implantation (PPVI) with Edwards Sapien 3 or Sapien XT valves for the treatment of right ventricular outflow tract (RVOT) defects.

Technology Description: The goal of PPVI is to improve hemodynamics, cardiopulmonary function, and survival while delaying the n…

Functional Electrical Stimulation for Foot Drop in Chronic Phase of Stroke Recovery

Focus of the Report: This Health Technology Assessment focuses on the use of functional electrical stimulation (FES) for treatment of foot drop in patients who have a history of stroke an average of ≥ 1 year prior to FES treatment. This mean 1-year threshold was implemented to ensure that the majority of enrolled patients within each study we…