Bardoxolone is an investigational oral nuclear factor erythroid-derived 2-related factor 2 (Nrf2) activator proposed to slow the progression of kidney disease in patients aged ≥ 12 years with chronic kidney disease caused by Alport Syndrome.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Mechanochemical Endovenous Ablation (MOCA) with the ClariVein Infusion Catheter Nonthermal Vein Ablation System (Merit Medical Systems Inc.) for Treatment of Varicose Veins
Focus of the Report: This Health Technology Assessment focuses on the use of mechanochemical endovenous ablation (MOCA), a nonthermal type of ablation for treatment of varicose veins, with the ClariVein infusion catheter (Merit Medical Systems Inc.).
Technology Description: The ClariVe…
Cell-Free DNA (cfDNA) (Formerly NIPS, NIPT) Screening for Fetal Chromosomal Copy Number Variants
This report evaluates the clinical utility of cell-free DNA (cfDNA) (formerly NIPS, NIPT) screening for fetal chromosomal copy number variants (CNVs) in women with singleton or twin pregnancies.
Powered Microprocessor Prosthetic Ankles in Patients with Transtibial Amputation
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of powered microprocessor prosthetic ankles for patients with transtibial amputation, compared with nonpowered prostheses, with a focus on patient-oriented outcomes.
The iovera° (Pacira BioSciences Inc.) System for Pain Associated with Total Knee Arthroplasty
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of cryoneurolysis/cryoanalgesia via the iovera° system for postoperative knee pain following total knee arthroplasty (TKA).
Sacral Nerve Stimulation for Treatment of Non-obstructive Urinary Retention
Focus of the Report: This report focuses on sacral nerve stimulation (SNS) for non-obstructive urinary retention (NOUR). The goal of this treatment is to improve bladder emptying.
Technology Description: SNS relies on implantation of a programmable device that applies low-level electri…
Cognilum Transcranial Photobiomodulation (tPBM) for Autism Spectrum Disorder
Cognilum is a wearable transcranial photobiomodulation (tPBM) device under investigation for the reduction of symptoms of moderate to severe autism spectrum disorder (ASD) in pediatric patients aged 2 to 6 years.
Platelet-Rich Plasma for Wound Treatment in Diabetic Foot Ulcers
Focus of the Report: This health technology assessment focuses on the use of platelet-rich plasma (PRP) for treatment of diabetic foot ulcers (DFUs).
Technology Description: PRP is an autologous blood preparation with a higher-than-usual concentration of platelets, platelet-derived gro…
Enjaymo (Sutimlimab-jome) for Cold Agglutinin Disease
Enjaymo (sutimlimab-jome) is an intravenous monoclonal antibody classical complement inhibitor indicated to decrease the need for red blood cell (RBC) transfusion due to hemolysis in adults with cold agglutinin disease.
Common Variable Immune Deficiency (CVID)
This report reviews clinical study abstracts and clinical practice guidelines addressing genetic testing for common variable immune deficiency (CVID).