Leqvio (inclisiran) is a subcutaneously administered, small interfering RNA (siRNA) directed to PCSK9 (proprotein convertase subtilisin kexin type 9) mRNA indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD), who requi…
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Superior Cluneal Nerve Block for Treatment of Low Back Pain
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of superior cluneal nerve (SCN) blocks for patients with lower back pain (LBP) thought to be due to SCN entrapment (SCN-E).
Intraoperative Neuromonitoring for Lumbar Spinal Fusion and Discectomy
Focus of Report: This report focuses on intraoperative neuromonitoring (IONM) for the detection and prevention of surgical manipulations that could cause nerve damage during lumbar spinal discectomy alone or discectomy plus fusion.
Technology Description: During discectomy or fusion of…
Hyperspectral Imaging for the Assessment of Lower Extremity Peripheral Artery Disease
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of hyperspectral imaging for the assessment of peripheral artery disease (PAD) of the lower leg, in terms of diagnosis (e.g., clinical validity) or informing clinical decision-making or impacting health outcomes (e.g., clinical…
Dorsal Root Ganglion Stimulation for the Treatment of Complex Regional Pain Syndrome
Focus of Report: The focus of this health technology assessment is to evaluate the safety and effectiveness of dorsal root ganglion (DRG) stimulation for the treatment of complex regional pain syndrome (CRPS) in adults.
Technology Description: The DRG is considered to have a gatekeeper…
Passive Microprocessor Prosthetic Ankles in Patients with Transtibial Amputation
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of passive microprocessor prosthetic ankles (MPAs) for patients with transtibial amputation compared with non-MPA prostheses for patient-centered outcomes.
Cell-Free DNA (cfDNA) [Formerly NIPS, NIPT] Screening for Fetal Rare Autosomal Trisomies
This report evaluates the clinical utility of cell-free DNA (cfDNA) (formerly noninvasive prenatal testing [NIPT] or noninvasive prenatal screening [NIPS]) screening for fetal rare autosomal aneuploidy (RAA) in women with singleton or twin pregnancies.
Vyvgart (Efgartigimod alfa-fcab) for Myasthenia Gravis
Vyvgart (efgartigimod alfa-fcab) is a first-in-class intravenously administered neonatal Fc receptor blocker indicated for the treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive.
Tezspire (Tezepelumab-ekko) for Severe Asthma
Tezspire (tezepelumab-ekko) is a thymic stromal lymphopoietin blocker human monoclonal antibody indicated for the add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma.
Tuberous Sclerosis Complex
This report reviews clinical study abstracts and clinical practice guidelines addressing genetic testing for tuberous sclerosis complex (TSC).