This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of subchondral calcium phosphate (SCP) injections for the treatment of pain and function impairment due to bone marrow lesions (BMLs) associated with knee osteoarthritis (KOA) and/or insufficiency fractures.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Whole Exome/Genome Sequencing for Previously Undiagnosed Pediatric Neurodevelopmental Disorders
This report evaluates the use of whole exome sequencing (WES) or whole genome sequencing (WGS) to inform clinical action and improve patient outcomes in children aged ≤ 18 years with undefined neurological phenotypes but no definitive diagnosis following standard diagnostic tests.
Whole Exome/Genome Sequencing for Previously Undiagnosed Pediatric Neurodevelopmental Disorders
This report evaluates the use of whole exome sequencing (WES) or whole genome sequencing (WGS) to inform clinical action and improve patient outcomes in children aged ≤ 18 years with undefined neurological phenotypes but no definitive diagnosis following standard diagnostic tests.
Livmarli (Maralixibat) for Cholestatic Pruritus in Alagille Syndrome (ALGS)
Livmarli (maralixibat) is an ileal bile acid transporter (IBAT) inhibitor indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS) 1 year of age and older.
Susvimo (Ranibizumab) Ocular Implant for Neovascular Age-related Macular Degeneration
Susvimo (ranibizumab injection) is a refillable ocular implant containing the vascular endothelial growth factor (VEGF) inhibitor ranibizumab indicated for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD) who have previously responded to at least two intravitreal injections of a VEGF inhibitor.
Platelet-Rich Plasma for Wound Treatment in Venous Leg Ulcers
Focus of the Report: This report focuses on the efficacy and safety of platelet-rich plasma (PRP) for treatment of venous leg ulcers (VLUs).
Technology Description: PRP is an autologous blood preparation with a higher-than-usual concentration of platelets, platelet-derived growth factors, and other cytokines. Protocols for PRP preparation vary consider…
Tenex (Tenex Health TX) Percutaneous Ultrasonic Tenotomy System to Treat Achilles Tendinopathy
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of Tenex (Tenex Health TX) to administer percutaneous ultrasonic tenotomy to reduce pain and improve quality of life and function in patients with Achilles tendinopathy.
Balstilimab for Cervical Cancer
Balstilimab is an investigational intravenous immunotherapy. It inhibits the activity of programmed death-1 (PD-1), an immune checkpoint protein that helps restrain the immune system. Balstilimab is proposed for the second-line treatment of advanced cervical cancer in patients with disease progression or who experience a relapse during or after chemotherapy.
Somryst (Pear Therapeutics Inc.) for Treatment of Insomnia
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of Somryst (Pear Therapeutics Inc.) for the treatment of chronic insomnia in adults.
Lungpacer Diaphragm Pacing Therapy System
The Lungpacer Diaphragm Pacing Therapy (DPT) system is a temporary, minimally invasive, transvenous phrenic nerve pacing system intended for treatment of patients on mechanical ventilation to facilitate weaning from the ventilator.