This report evaluates the clinical utility of cell-free DNA (cfDNA) (formerly NIPS, NIPT) screening for fetal trisomy 21, 18, and 13 in women with twin pregnancies.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Screening All Women with New Diagnoses of Breast Cancer for Hereditary Cancer Risk Variants
This report evaluates the clinical utility of genetic testing to detect hereditary cancer 1) high risk and 2) moderate risk gene variants in women with new diagnoses of breast cancer (BC), who are not preselected for other risk factors, to improve disease management.
Radiofrequency Ablation for Benign Thyroid Nodules
Focus of the Report: This report focuses on the use of radiofrequency ablation (RFA) for treatment of symptomatic benign thyroid nodules (BTNs) in adult patients.
Technology Description: RFA is an ultrasound (US)-guided, minimally invasive treatment approach, which applies high frequen…
Annular Closure for Prevention of Lumbar Disc Reherniation
Focus of the Report: This report focuses on annular closure for the prevention of recurrent lumbar disc herniation (LDH) after lumbar discectomy (LD).
Technology Description: Annular closure is a surgical treatment that is performed immediately following an LDH debridement surgery (e.g., l…
Ryplazim (Plasminogen, Human-tmvh) for Plasminogen Deficiency Type 1
Ryplazim is plasma-derived human plasminogen indicated for the treatment of patients with plasminogen deficiency type 1 (hypoplasminogenemia). Ryplazim is recovered from healthy donor plasma; plasminogen is extracted using a proprietary process. Purified isolated plasminogen is administered by intravenous infusion.
Lumakras (Sotorasib) for Non-Small Cell Lung Cancer
Lumakras (sotorasib) is an oral KRAS G12C inhibitor designed to block the abnormal proliferative action of mutant KRAS protein. It is indicated for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), as determined by an FDA-approved test, who hav…
Botulinum Toxin for Treatment of Pain Associated with Temporomandibular Disorders
Focus of the Report: This report focuses on the use of botulinum toxin (BTX) for treatment of pain associated with temporomandibular disorders.
Technology Description: BTX, a neurotoxin produced by the bacterium Clostridium (C.) botulinum, is classified into 8 …
AlloSure Kidney (CareDx Inc.)
This report evaluates the AlloSure Kidney test for acute and chronic kidney transplant rejection (antibody-mediated and/or T-cell mediated) in patients for either surveillance or for-cause evaluation.
Acupuncture for the Treatment of Allergic Rhinitis
Focus of the Report: This report focuses on acupuncture (AP) for treatment of allergic rhinitis.
Technology Description: Traditional AP employs thin metal needles to pierce the skin at specific, defined sites. Related treatments involve application of pressure, electrical stimulation (…
Nodify XL2 (Biodesix Inc.)
This report evaluates the analytical validity, clinical validity, and clinical utility of the Nodify XL2 test.