Trodelvy (sacituzumab govitecan-hziy) is an intravenously administered antibody-drug conjugate (ADC) indicated for the treatment of adult patients with metastatic triple-negative breast cancer (mTNBC) who have received at least 2 prior therapies for metastatic disease. Trodelvy is the first FDA-approved ADC indicated for the treatment of TNBC.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Botulinum Toxin for Treatment of Raynaud Phenomenon
Focus of the Report: For use of botulinum toxin (BTX) for Raynaud phenomenon (RP).
Technology Description: BTX has been investigated as a treatment for various chronic painful conditions because of its potential to reduce muscle tension and modulate pain receptor activity in the central nervous system. For the treatment of RP, there is currently no sta…
ProACT Adjustable Continence Therapy (Uromedica) for Treatment of Post-Surgical Urinary Incontinence in Men
Focus of the Report: Implantation of the ProACT device for the treatment of adult men with post-prostate surgery urinary incontinence (UI).
Technology Description: The ProACT system is a medical implantable device that consists of 2 sets of urethral balloons connected to titanium volume adjustment ports via tubing. During ProACT device implantation, a …
Transabdominal Cervical Cerclage (TAC) for the Prevention of Miscarriage and Preterm Delivery
Focus of the Report: The use of transabdominal cervical cerclage (TAC) for treatment of cervical insufficiency to prevent preterm delivery (PTD) or miscarriage.
Technology Description: TAC involves the placement of sutures to reinforce the cervix using a transabdominal approach. An al…
Reblozyl (Luspatercept) for Beta Thalassemia
Reblozyl is an erythroid maturation agent administered via subcutaneous injection indicated for the treatment of patients with transfusion-dependent beta thalassemia. This recombinant fusion protein is believed to help immature cells develop into red blood cells, thereby preventing anemia and reducing or eliminating the need for frequent blood transfusions.
Lopinavir/Ritonavir for COVID-19
Lopinavir/ritonavir is an oral antiretroviral protease inhibitor combination agent under investigation for the treatment of COVID-19. Lopinavir/ritonavir is FDA approved for use in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients aged 14 days and older.
Convalescent Plasma for Treatment of COVID-19
Convalescent plasma is a form of passive antibody therapy that is under investigation for the treatment of COVID-19. Convalescent plasma is collected from patients who have recovered from COVID-19 and administered to patients with active, symptomatic disease via intravenous infusion.
Magnetic Resonance Elastography for Prognosis of Liver Disease Progression
Focus of the Report: Magnetic resonance elastography (MRE) is a diagnostic test for assessing hepatic fibrosis, a form of liver damage that occurs when healthy tissue is replaced by stiff, fibrous scar tissue. This report focuses on MRE for prediction of serious potential consequences of liver disease such as development of cirrhosis or liver…
Scrambler/Calmare Pain Therapy (Calmare Therapeutics Inc.) for the Management of Pain not Related to Cancer
Focus of the Report: The use of Scrambler therapy (ST), also referred to as Calmare Pain Therapy and transcutaneous electrical modulation pain reprocessing (Calmare Therapeutics Inc.), for the management of chronic pain not related to cancer or cancer treatments.
Technology Description: ST is a noninvasive, transdermal treatment for the symptomatic rel…
Scrambler/Calmare Pain Therapy (Calmare Therapeutics Inc.) for the Management of Chronic Pain Related to Cancer or Cancer Treatment
Focus of the Report: Use of Scrambler therapy (ST), also referred to as Calmare Pain Therapy and transcutaneous electrical modulation pain reprocessing (Calmare Therapeutics Inc.), for the management of chronic pain related to cancer or cancer treatment.
Technology Description: ST is a…