This report evaluates the clinical utility of pharmacogenetic testing for CYP2D6 gene variants prior to prescribing codeine or tramadol to improve opioid treatment–related outcomes in pediatric patients with organic causes of pain.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Epidiolex for Treatment-Resistant Epilepsies Other than Lennox-Gastaut Syndrome or Dravet Syndrome
Health Problem: Epilepsy is one of the most common neurological disorders in the United States and has a prevalence of approximately 3 million adults and 470,000 children. Management generally involves treatment with antiepileptic drugs (AEDs), but for approximately 30% of patients, seizures will remain uncontrolled by medical therapy. In the…
Subtalar Arthroereisis for the Treatment of Pediatric Flatfoot
Health Problem: Flatfoot (FF) refers to a progressive developmental or acquired deformity characterized by plantar medial rotation of the talus, decrease in medial arch height, and abduction of the forefoot. In children, FF may be an isolated clinical entity or it may be found with neuromuscular disorders (e.g., cerebral palsy [CP]). Untreate…
Intense Pulsed Light Therapy for Dry Eye Disease
Health Problem: Dry eye disease (DED) is a type of ocular surface disorder. Meibomian gland dysfunction (MGD) contributes to DED in approximately 60% of patients. The meibomian glands (MGs) are present in the upper and lower eyelids and they secrete lipids that are an important component of tears. The oily lipids float to the surface of tear …
Continuous Subcutaneous Insulin Infusion with OmniPod Insulin Management System (Insulet Corporation) for Management of Diabetes Mellitus
Health Problem: Diabetes mellitus (DM) is a chronic, progressive disease characterized by impaired metabolism of carbohydrates. DM affects approximately 30 million Americans (9.4% of the population) and costs $327 billion annually in the United States.
Technology Description: The OmniP…
Canaloplasty for Open-Angle Glaucoma
Health Problem: Glaucoma is a disease of the optic nerve characterized by loss of retinal ganglion cells; remodeling of the lamina cribrosa; structural changes to the nerve; elevated intraocular pressure (IOP); and progressive, irreversible loss of vision leading to blindness. Open-angle glaucoma (OAG) is associated with partial blockage of t…
Ayvakit (Avapritinib) for Gastrointestinal Stromal Tumor
Ayvakit (avapritinib) is an oral potent and selective inhibitor of activated KIT and PDGFRA mutant kinases, particularly activation loop mutations and highly resistant PDGFRA D842V mutation. It is indicated for the treatment of adults with unresectable or metastatic gastrointestinal s…
Vazegepant for Acute Treatment of Migraine
Vazegepant is an intranasal novel small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist (“gepant”) drug proposed for the acute treatment of migraine headache. CGRP is involved in vasodilation and sensory transmission and is a validated target for the treatment of migraine headache.
Proton Beam Therapy for Treatment of Chordoma and Chondrosarcoma of the Skull Base
Health Problem: Chordomas are rare primary bone tumors originating from remnants of the embryonic notochord and most commonly arising in the skull base (32%), mobile spine (33%), and sacrum (29%). Chondrosarcomas, which arise from cartilage, are usually low-grade, indolent, invasive tumors that cause morbidity by compressing skull base neurov…
Thermal Pulsation for Chronic Dry Eye Syndrome and Meibomian Gland Dysfunction
Health Problem: Dry eye disease (DED) is a type of ocular surface disorder. Meibomian gland dysfunction (MGD) contributes to DED in approximately 60% of patients. The meibomian glands are present in the upper and lower eyelids and they secrete lipids that are an important component of tears. The oily lipids float to the surface of tear soluti…