This report evaluates the clinical utility of pharmacogenetic testing for:
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CYP2D6 gene variants prior to prescribing codeine or tramadol
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Single-gene variants in the CYP2D6, CYP3A…
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Prenatal and Preimplantation Genetic Testing for Risk of Hearing Loss
This report evaluates the
Prenatal and Preimplantation Genetic Testing for Risk of Hearing Loss
This report evaluates the
Pharmacogenetic and Pharmacogenomic Testing for Opioid Treatment for Pain in Adults – Selected Single-Gene Variants and Pharmacogenomic Panels
This report evaluates the clinical utility of pharmacogenetic testing for:
-
CYP2D6 gene variants prior to prescribing codeine or tramadol
-
Single-gene variants in the CYP2D6, CYP3A…
Wide-Area Transepithelial Sampling Biopsy for the Detection of Barrett’s Esophagus or Esophageal Dysplasia
Health Problem: Approximately 20% of the U.S. population is affected by gastroesophageal reflux disease (GERD). Persistent GERD may lead to esophageal damage and may precede other serious conditions, including Barrett’s esophagus, a precancerous condition that can proceed to potentially lethal esophageal adenocarcinoma. Patients who have Barr…
Satralizumab for Neuromyelitis Optica Spectrum Disorder
Satralizumab is an investigational anti-IL-6 receptor monoclonal antibody under FDA review for the treatment of neuromyelitis optica spectrum disorder in adults and adolescents. It is administered by subcutaneous injection.
Comparative Effectiveness Review of Peroral Endoscopic Myotomy for Treatment of Esophageal Achalasia
Health Problem: Esophageal achalasia (EA) is an uncommon motility disorder of unknown etiology that is characterized by increased lower esophageal sphincter (LES) pressure and esophageal aperistalsis. Treatment for EA includes both conservative treatment options, such as pharmaceutical therapies or botulinum toxin injection, and invasive opti…
Pharmacogenetic Testing for Opioid Treatment for Pain – OPRM1 and COMT Variants
This report evaluates the clinical utility of pharmacogenetic testing for OPRM1 and/or COMT gene variants to improve opioid treatment–related outcomes in patients with organic causes of pain.
Peroral Endoscopic Myotomy for Treatment of Esophageal Achalasia
Health Problem: Esophageal achalasia (EA) is an uncommon motility disorder of unknown etiology that is characterized by increased lower esophageal sphincter (LES) pressure and esophageal aperistalsis. Treatment for EA includes both conservative treatment options, such as pharmaceutical therapies or botulinum toxin injection, and invasive opti…
Pharmacogenetic Testing for Opioid Treatment for Pain – OPRM1 and COMT Variants
This report evaluates the clinical utility of pharmacogenetic testing for OPRM1 and/or COMT gene variants to improve opioid treatment–related outcomes in patients with organic causes of pain.