Health Problem: Chronic rhinosinusitis (CRS), which is the symptomatic inflammation of sinonasal mucosa, is one of the most prevalent chronic conditions, impacting from 5% to 15% of adults and costing the United States an estimated $6.9 to $9.9 billion per year. Differentiating CRS and recurrent acute rhinosinusitis (RARS) is challenging, so …
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
3D-Printed Orthopedic Implants
Health Problem: Damage to major joints, such as the knee, hip, or spine, may be caused by diseases and conditions such as osteoarthritis, rheumatoid arthritis, fracture, bone tumors, and osteonecrosis. Symptoms associated with these conditions include persistent pain and limited function. Joint replacement surgery (arthroplasty) and associate…
Laser Interstitial Thermal Therapy (LITT) for Treatment of Glioblastoma in Adults
Health Problem: Glioblastoma (GBM) is the most prevalent primary malignant intracranial tumor, representing as much as 16% of primary brain tumors. GBM is a fast-growing aggressive glioma that develops from glial cells in the brain. The overall prognosis is poor and even with the best standard of care, the median survival for adults with GBM …
MI TumorSeek (Caris Life Sciences)
This report evaluates the analytical validity, clinical validity, and clinical utility of the MI TumorSeek test.
iStent Inject Trabecular Micro-Bypass Stent (Glaukos Corp.) as a Standalone Procedure for Open-Angle Glaucoma
Health Problem: Glaucoma is a disease of the optic nerve characterized by loss of retinal ganglion cells, remodeling of the lamina cribrosa, structural changes to the nerve, elevated IOP, and progressive, irreversible loss of vision leading to blindness. Open-angle glaucoma (OAG) is associated with partial blockage of the flow of aqueous humo…
Ofev (Nintedanib) for Systemic Sclerosis-Associated Interstitial Lung Disease
Ofev (nintedanib) is a small molecule that inhibits multiple receptor tyrosine kinases that play an important role in the pathogenesis of fibrosis. The inhibition of these receptors is believed to decrease collagen and fibronectin formation, thereby slowing the rate of decline in pulmonary function in patients with systemic sclerosis.
Ofev (Nintedanib) for Systemic Sclerosis-Associated Interstitial Lung Disease
Ofev (nintedanib) is a small molecule that inhibits multiple receptor tyrosine kinases that play an important role in the pathogenesis of fibrosis. The inhibition of these receptors is believed to decrease collagen and fibronectin formation, thereby slowing the rate of decline in pulmonary function in patients with systemic sclerosis.
Polidocanol Endovenous Microfoam (Varithena) 1% for Treatment of Varicose Veins
Health Problem: Varicose veins are dilated, thickened, elongated, and twisted blood vessels that may appear thread-like or as grape-like clusters under the skin, most often on the legs. They are manifestations of chronic venous insufficiency, a condition characterized by dysfunction of the valves in veins, leading to increased blood pressure,…
Polidocanol Endovenous Microfoam (Varithena) 1% for Treatment of Varicose Veins
Health Problem: Varicose veins are dilated, thickened, elongated, and twisted blood vessels that may appear thread-like or as grape-like clusters under the skin, most often on the legs. They are manifestations of chronic venous insufficiency, a condition characterized by dysfunction of the valves in veins, leading to increased blood pressure,…
Proton Beam Therapy for Treatment of Rhabdomyosarcomas of the Head and Neck Region in Pediatric Patients
Health Problem: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma diagnosed in children and the third most common pediatric extracranial solid tumor. Although progress in the treatment for RMS has led to improved survival, some children have nonresponsive or recurrent disease, and current treatment modalities can lead to long-term…