Health Problem: Movement disorders, such as Parkinson disease (PD) and essential tremor (ET), are neurological conditions that can cause tremor that cannot be controlled with medication in some patients. ET is the most common movement disorder, affecting an estimated 7 million Americans and approximately 1% to 6% of the adult population > 40 …
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Radioactive Yttrium-90 Microspheres for the Treatment of Primary Unresectable Liver Cancer for Downstaging or as a Bridge to Transplantation or Surgery
Health Problem: Hepatocellular carcinoma (HCC) is the most common liver malignancy in the United States, accounting for approximately 90% of primary liver cancers. The definitive therapies for HCC are surgical resection, tumor ablation, and liver transplantation; however, most patients are not eligible for these therapies due to the overall b…
Risk-Reducing (Prophylactic) Salpingectomy
Health Problem: In the United States, ovarian cancer ranks fifth among cancer deaths. This type of cancer is often not detected at an early stage since early signs or symptoms are usually absent or easily overlooked. There is no effective method for screening women at normal risk for ovarian cancer.
Technology Description: Bilateral salpingectomy refer…
Xpovio (Selinexor) for Relapsed/Refractory Multiple Myeloma
Xpovio is a first-in-class oral selective inhibitor of the nuclear export protein exportin-1 (XPO1). Xpovio is believed to bind with and inhibit XPO1, causing tumor suppressor proteins to accumulate in the cell nucleus and inducing apoptosis in cancer cells while preserving normal cells. It is indicated to treat patients with heavily pretreated relapsed/refractory multiple my…
Xpovio (Selinexor) for Relapsed/Refractory Multiple Myeloma
Xpovio is a first-in-class oral selective inhibitor of the nuclear export protein exportin-1 (XPO1). Xpovio is believed to bind with and inhibit XPO1, causing tumor suppressor proteins to accumulate in the cell nucleus and inducing apoptosis in cancer cells while preserving normal cells. It is indicated to treat patients with heavily pretreated relapsed/refractory multiple my…
Greater Occipital Nerve Blocks for Treatment of Migraine
Health Problem: Migraine is a chronic, familial neurological disorder characterized by episodic headache attacks that are typically unilateral and often debilitating, lasting for hours or days and occurring multiple times per month. It is the third most prevalent illness in the world and considered the most disabling of the neurological disor…
Lutetium Lu 177 Dotatate (Lutathera, Advanced Accelerator Applications USA Inc) for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors
Health Problem: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a rare and heterogeneous group of neoplasms derived from neuroendocrine cells within the gastrointestinal tract and pancreas, where curative surgery options are limited. GEP-NETs are estimated to affect approximately 3 individuals per 100,000 people per year.
Grafix Cryopreserved Placental Membrane (Osiris Technologies Inc.) for Treatment of Chronic Foot Ulcers in Patients with Diabetes Mellitus
Health Problem: Diabetes can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of even minor wounds to heal. Chronic foot ulcers in people with diabetes may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Reasons are multifactorial and may include compromised s…
Barostim Neo System for Heart Failure
The Barostim neo System is an implantable neuromodulation device designed to improve cardiac function by delivering electrical stimulation to baroreceptors in the wall of the carotid artery. The system is designed to take advantage of the body’s natural baroreflex system. Activation of baroreceptors in the wall of the carotid artery with baroreflex activation therapy stimulat…
Barostim Neo System for Heart Failure
The Barostim neo System is an implantable neuromodulation device designed to improve cardiac function by delivering electrical stimulation to baroreceptors in the wall of the carotid artery. The system is designed to take advantage of the body’s natural baroreflex system. Activation of baroreceptors in the wall of the carotid artery with baroreflex activation therapy stimulat…