Health Problem: Ovarian cancer (OC) is the leading cause of death from gynecologic cancer in the United States and the fifth most common type of cancer-related death among women. In 2015, the 5-year survival rate for women diagnosed with OC was 47.6%. A woman’s risk of developing OC during her lifetime is 1 in 78; the risk of death from OC cancer is 1 in 108. The majority of …
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
CANCERPLEX (KEW Inc.)
This report evaluates the analytical validity, clinical validity, and clinical utility of the CANCERPLEX test. According to the laboratory, the test is intended to identify patients who are most likely to respond to immune checkpoint inhibition and detect the presence of human papilloma virus (HPV)/Epstein-Barr virus (EBV) viral integration, which may impact treatment decisio…
Magnetic Resonance–Guided Focused Ultrasound Therapy for Treatment of Uterine Fibroids
Health Problem: Uterine fibroids (UFs) (also called leiomyomata or myomas) are benign tumors of the myometrium, the smooth muscle layer of the uterus. Approximately 25% of fibroids are symptomatic. Fibroids are the most common indication for hysterectomy in many countries.
Technology Descript…
Magnetic Resonance–Guided Focused Ultrasound Therapy for Treatment of Uterine Fibroids
Health Problem: Uterine fibroids (UFs) (also called leiomyomata or myomas) are benign tumors of the myometrium, the smooth muscle layer of the uterus. Approximately 25% of fibroids are symptomatic. Fibroids are the most common indication for hysterectomy in many countries.
Technology Descript…
Botulinum Toxin Treatment for Migraine Headache
Health Problem: Headache is a common disorder affecting more than 45 million individuals in the United States. There are several types of headache, with symptoms that vary with the underlying pathophysiology. Headaches can be primary, such as migraine, cluster, and tension headaches; or secondary to systemic, intracranial, or extracranial causes. Migraine affects 18% of women…
Rozlytrek (Entrectinib)
Rozlytrek (entrectinib) is an oral tumor-agnostic agent intended to selectively inhibit the tyrosine kinase activity of TRKA, TRKB, TRKC, and ROS1 (ROS proto-oncogene 1 receptor tyrosine kinase) rearrangements. Rozlytrek is indicated for the treatment of adult and adolescent patients whose cancers have NTRK (neurotrophic tyrosine receptor kinase) gene fusion, and for whom the…
Balversa (Erdafitinib) for Urothelial Carcinoma
Balversa is an oral kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma that has susceptible fibroblast growth factor receptor 3 (FGFR3) or FGFR2 genetic alterations and has progressed during or following at least 1 line of prior platinum-containin…
Rozlytrek (Entrectinib)
Rozlytrek (entrectinib) is an oral tumor-agnostic agent intended to selectively inhibit the tyrosine kinase activity of TRKA, TRKB, TRKC, and ROS1 (ROS proto-oncogene 1 receptor tyrosine kinase) rearrangements. Rozlytrek is indicated for the treatment of adult and adolescent patients whose cancers have NTRK (neurotrophic tyrosine receptor kinase) gene fusion, and for whom the…
Balversa (Erdafitinib) for Urothelial Carcinoma
Balversa is an oral kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma that has susceptible fibroblast growth factor receptor 3 (FGFR3) or FGFR2 genetic alterations and has progressed during or following at least 1 line of prior platinum-containin…
The Early Start Denver Model for Treatment of Autism Spectrum Disorder
Health Problem: Autism spectrum disorder (ASD) is a neurodevelopmental condition that presents in childhood and is characterized by persistent deficits in social communication and social interaction; restricted, repetitive patterns of behavior, interests, or activities; and clinically significant impairment in social, occupational, or other i…