Sunosi is an oral phenylalanine-derived selective dopamine and norepinephrine reuptake inhibitor (DNRI). Norepinephrine inhibits rapid eye movement sleep and promotes wakefulness. Dopamine plays a role in areas of the brain responsible for sleep regulation. Sunosi is indicated for the improvement in wakefulness in adult patients with excessive sleepiness associated with narco…
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Sunosi (Solriamfetol)
Sunosi is an oral phenylalanine-derived selective dopamine and norepinephrine reuptake inhibitor (DNRI). Norepinephrine inhibits rapid eye movement sleep and promotes wakefulness. Dopamine plays a role in areas of the brain responsible for sleep regulation. Sunosi is indicated for the improvement in wakefulness in adult patients with excessive sleepiness associated with narco…
Turalio (Pexidartinib) for Tenosynovial Giant Cell Tumor
Turalio (pexidartinib) is an oral small molecule kinase inhibitor of colony stimulating factor-1 receptor (CSF1R) for treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations, and which is not amenable to improvement with surgery.
Turalio (Pexidartinib) for Tenosynovial Giant Cell Tumor
Turalio (pexidartinib) is an oral small molecule kinase inhibitor of colony stimulating factor-1 receptor (CSF1R) for treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations, and which is not amenable to improvement with surgery.
Genetic Testing for Common Forms of Hereditary Thrombophilia in Pediatric Patients with Unprovoked Venous Thromboembolism
This report evaluates the of genetic testing for common forms of hereditary thrombophilia in pediatric patients with unprovoked venous thromboembolism (VTE).
Nubeqa (Darolutamide) for Nonmestastatic CRPC
Nubeqa is a nonsteroidal second-generation androgen receptor inhibitor that competes with androgen by binding to the androgen receptor. It reduces the ability of androgen to promote the growth of prostate cancer cells. Nubeqa is indicated for the treatment of patients with nonmetastatic castration-resistant prostate cancer.
Nubeqa (Darolutamide) for Nonmestastatic CRPC
Nubeqa is a nonsteroidal second-generation androgen receptor inhibitor that competes with androgen by binding to the androgen receptor. It reduces the ability of androgen to promote the growth of prostate cancer cells. Nubeqa is indicated for the treatment of patients with nonmetastatic castration-resistant prostate cancer.
Genetic Testing for Common Forms of Hereditary Thrombophilia in Pediatric Patients with Unprovoked Venous Thromboembolism
This report evaluates the of genetic testing for common forms of hereditary thrombophilia in pediatric patients with unprovoked venous thromboembolism (VTE).
Intrathecal Opioids for Chronic Noncancer Pain
Health Problem: Chronic pain, or pain persisting > 6 months, is a multifaceted condition with an estimated prevalence of 2% to 40% in adults in the United States. There are numerous etiologies of chronic noncancer pain. Treatment of chronic pain depends on individual and pain-related factors. Common treatments include oral analgesics, injecti…
Brineura (Cerliponase Alfa)
Brineura is recombinant human tripeptidyl peptidase 1 (TPP1) replacement enzyme to slow loss of walking ability in symptomatic pediatric patients aged 3 years and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2). Brineura is infused into the cerebrospinal fluid (CSF) via an intraventricular access device implanted in the patient’s head. It is administere…