Health Problem: Prader-Willi syndrome (PWS) is a genetic disorder that is highly variable and can affect multiple body systems; there is an associated pattern of physical findings with significant cognitive, neurologic, endocrine, and behavioral abnormalities. Studies in the United States have reported a prevalence rate ranging from 1 per 16,…
Precision Medicine
The explosion of genetic and molecular medicine has produced mountains of options and evidence. Conversely, there is often an alarming lack of evidence. This is where we come in.We help you manage the flood of tests and drugs that emerge in this category daily. Accessed through the Hayes Knowledge Center, our comprehensive Precision Medicine solution focuses on thousands of genetic, genomic, and molecular diagnostic tests and precision medicine therapies addressing the questions our clients most frequently ask:
- Will testing change patient management for this indication?
- If so, what tests and/or therapies should I use?
- Should we cover testing and/or therapies?
- Can we manage these services internally?
- Precision Medicine Insights
- Precision Medicine Research Briefs
Liraglutide (Saxenda) For Weight Loss in Nondiabetic Obese Adults
Health Problem: The prevalence of obesity remains high in the United States. Recent estimates indicate that more than one-third of adults have obesity. Obesity is a serious health concern because it adversely affects mental health and quality of life, and is associated with leading causes of death, including diabetes, heart disease, stroke an…
AmniSure ROM Test for Detection of Fetal Membrane Rupture
Health Problem: During pregnancy, the fetal membranes contain the developing fetus and amniotic fluid and provide protection from infection. Although the membranes normally rupture during labor, in approximately 10% of pregnancies, rupture occurs before initiation of labor. Premature rupture of membranes (PROM) must be diagnosed accurately an…
Atezolizumab (Tecentriq) for Non-Small Cell Lung Cancer
Health Problem: Lung cancer is the second most common form of cancer in men (after prostate cancer) and women (after breast cancer), accounting for approximately 14% of all new cancers. Non-small cell lung cancer (NSCLC) accounts for > 80% of all lung cancer cases, and it includes 2 major types: non-squamous, including adenocarcinoma, large-c…
Cell-Free DNA (cfDNA) [Formerly NIPS, NIPT] Screening for Fetal Trisomy 21, 18, and 13 in High-Risk Women
This report evaluates the clinical utility for use of cell-free DNA (cfDNA) screening for fetal trisomy 21, 18, and 13 in high-risk women with singleton or multiple gestation pregnancies. Populations at high risk for aneuploidy include women with advanced maternal age; parental Robertsonian translocation involving chromosome 21 or 13; a previous pregnancy with a trisomy; ultrasound findings as…
Vectra DA Test (Crescendo Bioscience Inc.) for Management of Patients with Rheumatoid Arthritis
Health Problem: Rheumatoid arthritis (RA) is a chronic, progressive, systemic inflammatory disease leading to destruction of joint cartilage and bone, with consequent disability. This disease affects > 1.3 million people in the United States and > 4 million persons worldwide. Several new disease-modifying antirheumatic drugs (DMARDs) have bee…
Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Obesity in Women with Polycystic Ovary Syndrome
Health Problem: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 6% to 20% of women of reproductive age. It is characterized by oligoovulation (menstrual irregularity), hyperandrogenism (increased testosterone levels), and polycystic ovaries. Obesity is a common feature of PCOS, affecting approximately 40% to 80% of w…
Teduglutide (Gattex; Shire-NPS Pharmaceuticals Inc.) to Reduce Parenteral Support Requirements in Adults with Short Bowel Syndrome
Health Problem: Short bowel syndrome (SBS) is a rare malabsorptive condition in which the bowel is anatomically or functionally inadequate to meet absorptive nutritional needs. The goal of SBS therapy is to optimize enteral autonomy and reductions in parenteral support (PS) requirements, which is associated with morbidity, complications, redu…
Genetic Testing for Familial Hemiplegic Migraine (FHM)
This report evaluates the clinical utility of genetic testing for familial hemiplegic migraine (FHM) in symptomatic individuals who meet clinical diagnostic criteria for FHM and for asymptomatic family members who have a relative with FHM and a known pathogenic variant.
Cell-Free DNA (cfDNA) [Formerly NIPS, NIPT] Screening for Fetal Rare Autosomal Trisomies
This report evaluates the clinical utility for use of cell-free DNA (cfDNA) screening for rare autosomal trisomies in women with singleton or multiple gestation pregnancies. There has been a large uptake of cfDNA fetal screening for common trisomies in women at high risk for fetal aneuploidy, with the majority of fetal cfDNA studies published in high-risk populations. In addition, some profess…