This report evaluates the clinical utility for CYP2C19 pharmacogenomic genotyping to direct clopidogrel therapy in adult patients undergoing percutaneous coronary intervention (PCI).
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CYP2C19 Pharmacogenomic Genotyping to Direct Clopidogrel Therapy for Secondary Prevention in Patients with a History of Stroke and/or Transient Ischemic Attack (TIA)
This report evaluates the clinical utility for CYP2C19 pharmacogenomic genotyping to direct clopidogrel therapy for secondary prevention in adult patients who have experienced a stroke or transient ischemic attack (TIA).
Cell-Free DNA (cfDNA) [Formerly NIPS, NIPT] Screening for Fetal Chromosomal Copy Number Variants
This report evaluates the clinical utility for use of cell-free DNA (cfDNA) screening for fetal chromosomal copy number variants (CNVs) in women with singleton or multiple gestation pregnancies. There has been a large uptake of cfDNA fetal screening for common trisomies in women at high risk for fetal aneuploidy, with the majority of fetal cfDNA studies published in high-risk populations. In a…
Cell-Free DNA (cfDNA) [Formerly NIPS, NIPT] Screening for Fetal Sex Chromosome Aneuploidy
This report evaluates the clinical utility for use of cell-free DNA (cfDNA) screening for sex chromosome aneuploidies (SCAs) in women with singleton or multiple gestation pregnancies. There has been a large uptake of cfDNA fetal screening for common trisomies in women at high risk for fetal aneuploidy, with the majority of fetal cfDNA studies published in high-risk populations. In addition, so…
Zepatier (Grazoprevir and Elbasvir) for Chronic Hepatitis C Infection
Rationale: The nonstructural proteins (NS) 3, 4A, and 5A (NS3, NS4A, and NS5A) are key enzymes in hepatitis C virus (HCV) RNA replication. Drugs targeting these enzymes are expected to inhibit HCV replication, thus lowering viral loads.
Technology Description: Zepatier (grazoprevir, 10…
Cell-Free DNA (cfDNA) [Formerly NIPS, NIPT] Screening for Fetal Trisomy 21, 18, and 13 in Low-Risk Women
This report evaluates the clinical utility for use of cell-free DNA (cfDNA) screening for fetal trisomy 21, 18, and 13 in low-risk women with singleton or multiple gestation pregnancies. There has been a large uptake of cfDNA fetal screening in women at high risk for fetal aneuploidy, with the majority of fetal cfDNA screening studies published in high-risk populations. Some professional socie…
Ocrelizumab (Ocrevus; Genentech Inc.) for Primary Progressive and Relapsing-Remitting Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disorder that impacts the spinal cord and brain. MS presents in various forms, including relapsing-remitting MS (RRMS) or primary progressive MS (PPMS).
Technology Description: Ocrelizumab (Ocrevus) is a humanized monoclonal antibody therapy that is directed toward cluster of di…
Adoptive Immunotherapy Using Genetically Modified Lymphocytes for Lymphoproliferative Disorders and Hematological Malignancies
Rationale: CAR T cells and genetically engineered TCR T cells are targeted, personalized therapies for malignancies and other neoplastic disorders, including hematological cancers and lymphoproliferative diseases. Although alternative treatments, including chemotherapy, radiation, monoclonal antibodies, hematopoietic stem cell transplants (HS…
MTHFR Genetic Testing for Severe MTHFR Enzyme Deficiency
This report evaluates the clinical utility for MTHFR genotyping in pediatric or adult patients to detect rare variants in order to improve case identification as well as treatment or family planning outcomes.
MTHFR Genetic Testing in Common Clinical Conditions
This report evaluates the clinical utility for MTHFR genotyping in pediatric or adult patients to detect common variants and support genotype-directed treatment of common conditions.