This report examines the clinical utility of genetic testing for germline variants in patients with a personal history of breast and/or ovarian cancer and a family history suggestive of hereditary breast and ovarian cancer (HBOC). This report provides an assessment of the evidence for the use of genetic testing in this patient population. The goal of the report is to assess how genetic testing of patients with a personal history of cancer changes patient management, informs treatment selection and/or prognosis, and impacts at-risk family members.
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